MCM7 is a core component of the MCM2-7 replicative helicase complex essential for DNA replication initiation and elongation in eukaryotic cells 1. As part of the CMG helicase, MCM7 unwinds template DNA during replication and contributes to the active ATPase sites of the MCM complex through conserved arginine finger motifs 1. Beyond its canonical replication role, MCM7 is implicated in multiple disease contexts. MCM7 knockdown triggers cellular senescence markers including p16/p21 activation and morphological changes 2, suggesting involvement in cell cycle checkpoint regulation. In hepatocellular carcinoma, MCM7 expression is enhanced by histone lactylation and promotes cancer stem cell properties and radio-resistance; MCM7 suppression sensitizes tumors to radiotherapy 3. MCM7 also drives liver fibrosis by transcriptionally regulating IL11 via the SHCBP1-RACGAP1-STAT3 axis, promoting hepatic stellate cell activation 4. In esophageal cancer, PLCE1 enhances MCM7 transcription and phosphorylation at threonine residues via RIOK2-mediated modification, promoting cell-cycle progression and tumor progression; MCM7 overexpression correlates with poor survival 5. MCM7 is frequently overexpressed in multiple malignancies including leukemia and gastric cancer, with prognostic implications 67.