MOB3C (MOB kinase activator 3C) is a member of the monopolar spindle-one-binder (MOB) protein family that functions as an adaptor protein mediating protein-protein interactions. MOB3C localizes to the cytoplasm and nucleus where it exhibits protein kinase activator activity and participates in signal transduction 1. The primary biochemical function of MOB3C involves regulation of kinase activity through protein-protein interactions. A unique biological role for MOB3C was recently discovered: it interacts specifically with seven of ten protein subunits of the RNase P complex, an endonuclease responsible for tRNA 5' maturation, linking MOB3C to RNA processing pathways 1. Clinically, MOB3C variants show associations with multiple cardiovascular and metabolic diseases. Genetic variants in the MOB3C-TMOD4 locus have been identified as novel susceptibility loci for hypertension and chr1 kidney disease in Japanese populations 2, as well as for early-onset dyslipidemia, specifically hypo-HDL-cholesterolemia 3. Additionally, MOB3C was identified among genes with previously unreported associations with coronary artery disease through gene-based association analyses 4. MOB3C variants have also been identified in colorectal cancer patient cohorts, suggesting potential involvement in cancer predisposition 5. These findings indicate that MOB3C dysfunction may contribute to cardiovascular disease pathogenesis, though the precise mechanistic links between MOB3C variants and disease phenotypes require further investigation.