ZNF77 (zinc finger protein 77) is a transcriptional regulator located on chromosome 19 that functions as a DNA-binding transcription factor for RNA polymerase II 1. The protein contains zinc finger motifs enabling sequence-specific DNA binding and nuclear localization for transcriptional regulation [GO annotations cited in provided data]. ZNF77 plays a critical role in controlling airway epithelial integrity and fungal susceptibility. The genetic variant rs35699176 (Q100*), a nonsense mutation causing premature truncation, disrupts bronchial epithelium integrity and increases extracellular matrix proteins, promoting Aspergillus fumigatus conidial adhesion and germination 2. Patients carrying this variant exhibit higher fungal loads in respiratory airways, suggesting ZNF77 as a key controller of Aspergillus colonization. ZNF77 mutations associate with multiple disease conditions. The Q100* variant links to elevated plasma IL-12 in fibromyalgia syndrome patients (11% prevalence) 3 and increased fasting growth hormone levels 4. ZNF77 variants also confer susceptibility to early-onset myocardial infarction and chr19 kidney disease 5, and hypo-HDL-cholesterolemia 6. Additionally, ZNF77 frameshift mutations in Meckel-Gruber syndrome fetuses suggest involvement in sonic hedgehog (SHH) signaling pathway regulation 7. Clinically, ZNF77 genotyping may inform genetic risk assessment for cardiovascular, renal, lipid, and fungal infection susceptibility.