1 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
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31PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
mitochondrionmitochondrial large ribosomal subunitmitochondrial translationstructural constituent of ribosomeneurodegenerative diseaseAlzheimer diseaseParkinson diseaselysosomal storage disease
MRPL34 is a mitochondrial ribosomal protein that functions as a structural constituent of the mitochondrial large ribosomal subunit, participating in mitochondrial translation. Based on limited published evidence, a Mendelian randomization study predicted a causal relationship between elevated MRPL34 levels and increased susceptibility to sensorineural hearing loss (SNHL) 1, suggesting MRPL34 may contribute to hearing loss pathogenesis through mitochondrial dysfunction.
1
Elevated MRPL34 levels were associated with increased risk of sensorineural hearing loss in Mendelian randomization analysis (OR = 1.0458, p = 0.0362)
PMID: 39052887⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
Alzheimer diseaseOpen Targets
Parkinson diseaseOpen Targets
lysosomal storage diseaseOpen Targets
multiple sclerosisOpen Targets
triple-negative breast cancerOpen Targets
atrial fibrillationOpen Targets
ovarian serous adenocarcinomaOpen Targets
breast carcinomaOpen Targets
estrogen-receptor negative breast cancerOpen Targets
breast cancerOpen Targets
ovarian carcinomaOpen Targets
retinal edemaOpen Targets
squamous cell lung carcinomaOpen Targets
ulcerative colitisOpen Targets
sensorineural hearing lossOpen Targets
juvenile dermatomyositisOpen Targets
No pathogenic variants reported on ClinVar for this gene.