Based on limited published evidence, MRPL45 is a mitochondrial ribosomal protein functioning as a structural constituent of the mitochondrial large ribosomal subunit. It localizes to the mitochondrial inner membrane and participates in mitochondrial translation through RNA binding and protein-protein interactions. MRPL45 was identified as a potential genetic modifier in a whole exome sequencing study of hereditary angioedema patients 1, though its specific role in this condition remains undefined.