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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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MSC
musculin
Chromosome 8 · 8q13.3
NCBI Gene: 9242Ensembl: ENSG00000178860.10HGNC: HGNC:7321UniProt: O60682
24PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nucleoplasmsequence-specific double-stranded DNA bindingRNA polymerase II cis-regulatory region sequence-specific DNA bindingprotein bindingovarian neoplasmcervical carcinomaopen-angle glaucomacutaneous melanoma
✦AI Summary

I cannot provide a gene function summary for MSC (musculin) based on the provided abstracts. While the abstracts contain extensive information about mesenchymal stem cells (MSC) and their therapeutic applications, they do not address the musculin gene itself, its transcriptional mechanisms, or its biological functions. The provided literature focuses on characterizing MSC cell populations, their differentiation capacity, exosome-derived therapeutic effects in various disease models (liver fibrosis, cardiotoxicity, wound healing), and age-related changes in MSC properties 12345678. None of these sources discuss musculin as a transcription factor, its role in inhibiting TCF3/E47, B-cell differentiation regulation, or its functions in muscle development and cardiac conduction—all of which are mentioned in the UniProt and GO annotations. To provide an evidence-based summary of musculin's gene function, abstracts from studies specifically investigating this transcription factor would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
ovarian neoplasmOpen Targets
0.32Weak
cervical carcinomaOpen Targets
0.31Weak
open-angle glaucomaOpen Targets
0.29Weak
cutaneous melanomaOpen Targets
0.29Weak
connective tissue diseaseOpen Targets
0.27Weak
hidradenitisOpen Targets
0.26Weak
Abnormal pupillary functionOpen Targets
0.22Weak
adolescent idiopathic scoliosisOpen Targets
0.21Weak
premature birthOpen Targets
0.16Weak
smoking behaviorOpen Targets
0.15Weak
glaucomaOpen Targets
0.14Weak
DNA methylationOpen Targets
0.13Weak
parathyroid diseaseOpen Targets
0.12Weak
Abruptio PlacentaeOpen Targets
0.12Weak
hyperparathyroidismOpen Targets
0.11Weak
obesityOpen Targets
0.10Suggestive
systemic lupus erythematosusOpen Targets
0.07Suggestive
ApneaOpen Targets
0.06Suggestive
non-alcoholic fatty liver diseaseOpen Targets
0.06Suggestive
facial morphologyOpen Targets
0.04Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
HES6Protein interaction82%AKR7A3Protein interaction75%MYF5Protein interaction72%TCF3Protein interaction72%ZBTB18Shared pathway25%RTL1Shared pathway20%
Tissue Expression6 tissues
Heart
100%
Lung
98%
Ovary
66%
Bone Marrow
48%
Liver
43%
Brain
34%
Gene Interaction Network
Click a node to explore
MSCHES6AKR7A3MYF5TCF3ZBTB18RTL1
PROTEIN STRUCTURE
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AlphaFoldAI-predicted · UniProt O60682
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
1.78LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF1.22 [0.82–1.78]
RankingsWhere MSC stands among ~20K protein-coding genes
  • #13,244of 20,598
    Most Researched24
  • #16,494of 17,882
    Most Constrained (LOEUF)1.78
Genes detectedMSC
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.
PMID: 16923606
Cytotherapy · 2006
1.00
2
Isolation, cultivation, and characterization of human mesenchymal stem cells.
PMID: 29072818
Cytometry A · 2018
0.90
3
Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway.
PMID: 37328872
J Nanobiotechnology · 2023
0.80
4
Exosomal miR-9-5p derived from iPSC-MSCs ameliorates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence.
PMID: 38643173
J Nanobiotechnology · 2024
0.70
5
Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis.
PMID: 25638205
J Transl Med · 2015
0.60