Based on limited published evidence, MYL11 encodes a myosin regulatory light chain essential for maintaining muscle integrity during early development and muscle contraction through actin-myosin filament sliding. The protein functions as a structural component of muscle myosin complexes and exhibits calcium ion binding capacity. MYL11 is associated with arthrogryposis, distal, 1C. Recent proteomic studies identified MYL11 as significantly elevated in plasma and cerebrospinal fluid of amyotrophic lateral sclerosis patients 1, suggesting a role as a muscle-derived biomarker in neuromuscular disease.