MTMR10 (myotubularin related protein 10) is a gene located at chromosome 15.3 that is implicated in various neuropsychiatric and developmental disorders through genomic deletions and duplications. MTMR10 is one of six genes commonly deleted in the 15q13.3 microdeletion syndrome, which is associated with intellectual disability, epilepsy, autism spectrum disorder, and schizophrenia 1 2. Mouse models with heterozygous deletions encompassing Mtmr10 exhibit increased seizure susceptibility, impaired spatial learning, and behavioral abnormalities relevant to autism and schizophrenia phenotypes 2 1. The protein localizes to cytoplasm, membrane, and cytosol compartments. Recent studies have identified MTMR10 variants associated with colorectal cancer susceptibility, where the rs3743231 CC genotype increases cancer risk through modulation of gene expression 3. Additionally, rare damaging variants in MTMR10 have been correlated with ADHD risk, suggesting involvement in immune processes and late-infancy cerebellar development 4. Prenatal deletions involving MTMR10 are associated with cardiovascular malformations and lateral ventriculomegaly 5. The gene also shows female-specific differential expression patterns in lung adenocarcinoma, where downregulation correlates with poor prognosis 6. However, the precise molecular mechanism of MTMR10 function remains incompletely characterized in the current literature.