MX2 (MX dynamin-like GTPase 2) is an interferon-induced GTPase that functions as a potent antiviral restriction factor against multiple viruses, particularly HIV-1 and herpesviruses 1. The protein exerts its antiviral activity through a unique mechanism involving the formation of cytoplasmic biomolecular condensates containing nucleoporin proteins that act as nuclear pore decoys 2. These condensates trap incoming viral capsids and prevent nuclear entry of viral genomes, causing premature genome release and disrupting nuclear targeting 2. MX2's antiviral function requires dimerization or oligomerization and depends on its disordered N-terminal region, though GTP hydrolysis is only necessary for herpesvirus inhibition 1. Beyond its antiviral role, MX2 appears to have tumor suppressor functions, as overexpression suppresses cell proliferation, migration, and invasion in glioblastoma cells through modulation of ERK/P38/NF-κB signaling pathways 3. The protein shows nuclear localization and exhibits constitutive low-level expression that is upregulated by interferon stimulation 4. MX2 represents a versatile interferon-stimulated gene with broad antiviral activity against both RNA and DNA viruses 5.