MYADM (myeloid associated differentiation marker) is a seven-transmembrane protein that functions as a critical regulator of cell migration, vascular remodeling, and viral entry. The protein is ubiquitously expressed across tissues except thymus and shows increased expression during myeloid differentiation, being upregulated in peripheral blood leukocytes compared to bone marrow cells 1. MYADM enables cancer cell metastasis by activating RhoA-mediated amoeboid migration through interaction with RhoGDI, promoting invasiveness, membrane blebbing, and anoikis resistance 2. In pulmonary vascular disease, MYADM contributes to pathological remodeling by promoting smooth muscle cell proliferation via a KLF4/p21-dependent mechanism, with its expression regulated by miR-182-3p 3. The protein plays a role in balancing BMP and TGF-β signaling pathways in pulmonary hypertension 4. Additionally, MYADM serves as a multi-genotype receptor for human parechoviruses, binding viral particles through its fourth extracellular loop and mediating post-attachment viral entry 5. In respiratory disease, MYADM expression is upregulated in type 2 asthma and following rhinovirus infection, where it promotes inflammatory gene expression 6. These diverse functions position MYADM as a potential therapeutic target for metastasis, pulmonary hypertension, and viral infections.