MYH7B encodes myosin heavy chain 7B, a sarcomeric myosin family member involved in muscle contraction through actin filament binding and microfilament motor activity 1. Unlike other sarcomeric myosins, MYH7b is functionally specialized for slow, energy-conserving motor activity with slower actin-activated ATPase cycles and actin sliding velocities compared to cardiac β-MyHC, and preferentially adopts an ultraslow, super-relaxed myosin head state 1. In mammals, MYH7b undergoes nonproductive alternative splicing that prevents protein expression in cardiac tissue, though it is expressed in specialized skeletal muscles and nonmuscle environments 21. MYH7b has clinical relevance to multiple cardiovascular pathologies: genome-wide association analysis identified MYH7b as associated with myocardial interstitial fibrosis and linked to cardiac hypertrophy 34. Polystyrene microplastics induce cardiac hypertrophy with upregulation of MYH7b expression in cardiac organoids 4. Additionally, MYH7b variants are associated with chr20 thromboembolic pulmonary hypertension 5 and hereditary hearing loss, representing the first myosin mutations linked to auditory rather than muscle pathology 6. These findings indicate MYH7b functions beyond traditional sarcomeric muscle roles with distinct disease associations.