TRPC7 is a calcium-permeable, non-selective cation channel that functions as a receptor-activated ion channel 1. It is primarily activated through G-protein-coupled receptor (GPCR) signaling, particularly Gαq-coupled pathways 2, operating downstream of phospholipase C (PLC) activation. TRPC7 is directly activated by diacylglycerol (DAG), a PLC product, and is regulated by phosphatidylinositol-4,5-bisphosphate (PIP2) depletion 3. The channel exhibits distinctive properties including constitutive activity and negative regulation by extracellular calcium and protein kinase C 14. Physiologically, TRPC7 regulates calcium homeostasis and mediates store-operated calcium entry 3. In the cardiovascular system, TRPC7 localizes to cardiomyocyte sarcolemma and is downregulated in cardiac hypertrophy associated with renovascular hypertension 5. Pathologically, TRPC7 plays a pivotal role in ultraviolet B-induced skin aging and tumorigenesis through rapid calcium influx and reactive oxygen species production, with TRPC7 knockout mice showing reduced UVB-associated pathology and tumor development 6. Additionally, a long non-coding RNA regulatory axis involving TRPC7-AS1 promotes hepatocellular carcinoma progression 7. These findings suggest TRPC7 functions as both a calcium signaling regulator in normal physiology and a potential tumor initiator gene in pathological conditions.