MYO5C encodes myosin VC, an actin-based motor protein predominantly expressed in epithelial and glandular tissues including pancreas, prostate, and mammary glands 1. Primary Function: MYO5C functions as a molecular motor powering actin-dependent membrane trafficking, particularly in secretory granule and transferrin trafficking 12. Mechanism: MYO5C localizes to two distinct compartments—small puncta containing secretory granule markers (chr15 A, Rab27b) moving at ~30 nm/s, and tubules marked by Rab8a moving at ~440 nm/s 2. Although individual MYO5C molecules are non-processive, coupling of two or more MYO5C dimers enables processive movement along actin filaments through increased F-actin binding affinity and stochastic stepping in 30-36 nm increments 3. Motor function is regulated by the globular tail domain through a Ca²⁺-sensitive inhibition mechanism conserved across class V myosins 4. Disease Relevance: MYO5C expression associates with Alzheimer's disease progression, with altered expression levels correlating with neurofibrillary tangle burden and late-onset AD development; protein interaction analysis suggests functional failure of MYO5C and PHYHD1 may contribute to AD pathogenesis 5. Clinical Significance: Particular high expression in pancreatic β-cells suggests roles in insulin secretion 6, and MYO5C involvement in viral trafficking indicates potential therapeutic targets for dengue virus infections 7.