Based on limited published evidence, NAT14 is a putative N-acetyltransferase with roles in transcriptional regulation. UniProt annotations indicate NAT14 may act as a transcription factor regulating coproporphyrinogen oxidase expression and possess N-acetyltransferase activity. NAT14 localizes to the nucleus and positively regulates DNA-templated transcription. Recent research demonstrates NAT14 functions as a binding partner for micropeptide MOXI and transcription factor c-Jun, forming a complex that enhances fibrotic gene expression in kidney disease 1. Notably, NAT14 does not catalyze N-acetylaspartate synthesis, unlike the related NAT8L enzyme 2.