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10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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NAV1
neuron navigator 1
Chromosome 1 · 1q32.1
NCBI Gene: 89796Ensembl: ENSG00000134369.17HGNC: HGNC:15989UniProt: A0A8I5KSE4
73PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingaxon initial segmentmicrotubule bundle formationneuron migrationVaricose veinstype 2 diabetes mellitusKeloidovarian dysfunction
✦AI Summary

NAV1 (neuron navigator 1) is primarily involved in neuronal migration and cytoskeletal organization. Based on available GO annotations, NAV1 participates in microtubule bundle formation and microtubule cytoskeleton dynamics within the nervous system, contributing to neuron migration during development. However, the provided PubMed abstracts do not contain specific information about NAV1's molecular mechanism, cellular function, or disease relevance. The abstracts focus on voltage-gated sodium channels (Nav1.7, Nav1.8, Nav1.9) encoded by SCN genes, which are distinct from NAV1. These sodium channels regulate neuronal excitability and are implicated in epilepsy, pain disorders, and small fiber neuropathy 1234, but these findings do not directly apply to the NAV1 protein. Without abstracts specifically characterizing NAV1 function, protein interactions, or associated pathologies, a comprehensive gene function summary cannot be provided. The UniProt annotation suggesting involvement in neuronal migration and the GO annotations indicating microtubule organization represent the current known functions, but mechanistic details, disease associations, and clinical significance remain undefined in the provided literature.

Sources cited
1
Documents sodium channel function in neurodevelopmental disorders; distinguishes voltage-gated sodium channels from NAV1
PMID: 33531663
2
Describes Nav1.8 (SCN10A-encoded) function in nociceptive neurons; unrelated to NAV1
PMID: 40010720
3
Reviews sodium channel variants in small fiber neuropathy; references SCN9A, SCN10A, SCN11A genes encoding Nav channels distinct from NAV1
PMID: 39433284
4
Analyzes SCN1A/2A/3A/8A sodium channel epilepsies; documents sodium channel biology separate from NAV1 function
PMID: 32090326
⚠Limited data available — This gene has 4 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Varicose veinsOpen Targets
0.32Weak
type 2 diabetes mellitusOpen Targets
0.28Weak
KeloidOpen Targets
0.27Weak
ovarian dysfunctionOpen Targets
0.27Weak
vertebral disorderOpen Targets
0.26Weak
cellulitisOpen Targets
0.23Weak
Abnormality of the skeletal systemOpen Targets
0.23Weak
aortic stenosisOpen Targets
0.23Weak
urinary bladder cancerOpen Targets
0.22Weak
hypertensionOpen Targets
0.21Weak
diabetic polyneuropathyOpen Targets
0.21Weak
nephrotic syndromeOpen Targets
0.20Weak
abscessOpen Targets
0.19Weak
venous thromboembolismOpen Targets
0.19Weak
placenta praeviaOpen Targets
0.18Weak
diabetes mellitusOpen Targets
0.16Weak
aortic valve calcificationOpen Targets
0.16Weak
coronary atherosclerosisOpen Targets
0.14Weak
cardiovascular diseaseOpen Targets
0.14Weak
occlusion precerebral arteryOpen Targets
0.14Weak
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
SCN1AProtein interaction77%SCN2AProtein interaction77%SCN2BProtein interaction77%SCN3AProtein interaction77%SCN4AProtein interaction77%SCN5AProtein interaction77%
Tissue Expression6 tissues
Brain
100%
Heart
79%
Lung
30%
Bone Marrow
19%
Ovary
13%
Liver
6%
Gene Interaction Network
Click a node to explore
NAV1SCN1ASCN2ASCN2BSCN3ASCN4ASCN5A
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q8NEY1
View on AlphaFold ↗
RankingsWhere NAV1 stands among ~20K protein-coding genes
  • #6,487of 20,598
    Most Researched73
Genes detectedNAV1
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Sodium channelopathies in neurodevelopmental disorders.
PMID: 33531663
Nat Rev Neurosci · 2021
1.00
2
Suzetrigine: The first Nav1.8 inhibitor approved for the treatment of moderate to severe acute pain.
PMID: 40010720
Drug Discov Ther · 2025
0.90
3
The Evolving Landscape of Small Fiber Neuropathy.
PMID: 39433284
Semin Neurol · 2025
0.80
4
Structure of the human voltage-gated sodium channel Na
PMID: 30190309
Science · 2018
0.70
5
Biological concepts in human sodium channel epilepsies and their relevance in clinical practice.
PMID: 32090326
Epilepsia · 2020
0.60