NCMAP (non-compact myelin associated protein) is a structural component of peripheral nervous system myelin with roles in myelin formation and maintenance. Based on GO annotations and sequence localization data, NCMAP localizes to paranodal regions and Schmidt-Lanterman incisures of myelinated axons, suggesting involvement in myelin organization at these specialized structures. The gene positively regulates myelination processes in the peripheral nervous system. At the molecular level, NCMAP functions as a structural constituent of the myelin sheath, likely contributing to the mechanical integrity and organization of non-compact myelin domains. Its precise biochemical mechanism remains to be fully characterized, though its localization pattern suggests roles in axonal insulation and myelin stability. Clinical relevance of NCMAP is emerging in two contexts. First, altered NCMAP expression has been identified in pre-eclamptic placentae, where it was among 53 differentially expressed genes associated with disturbed vascular function 1. Second, a genetic variant NCMAP rs4553122 was identified as significantly associated with peak anti-Factor Xa levels in patients receiving rivaroxaban anticoagulation therapy for nonvalvular atrial fibrillation, suggesting potential involvement in pharmacodynamic variation 2. These findings indicate NCMAP may have broader physiological functions beyond myelin structure, though additional investigation is needed to establish causal relationships and clinical significance.