NEMP1 is a nuclear envelope integral membrane protein with conserved roles in fertility and mechanotransduction. Biochemically, NEMP1 localizes to the inner nuclear membrane and forms a complex with EMERIN to support nuclear envelope mechanical stiffness 1. In germ cells, NEMP1 contributes to specialized nuclear envelope properties essential for fertility; loss of NEMP1 causes oocyte death in mechanically challenging environments, a phenotype rescued by softening ovarian tissue 2. NEMP1 also forms a complex with NESPRIN proteins to regulate YAP-dependent mechanotransduction independently of canonical LINC complexes, enabling cellular response to mechanical stress through actin organization 2. Disease relevance includes female fertility defects across multiple model organisms 1, though notably, male NEMP1 knockout mice retain fertility 3. In cancer, NEMP1 is upregulated in tamoxifen-resistant breast cancer cells and promotes resistance by modulating NCOA1 4. NEMP1 was also identified as a super-enhancer-associated gene in anaplastic thyroid carcinoma 5. Additionally, NEMP1 participates in nuclear lipid droplet regulation 6 and Xenopus eye development through BAF interactions 7. TMEM194A (NEMP1's alternative designation) is a target of the tumor-suppressive microRNA miR-1285-5p in breast cancer 8.