NFYC encodes the gamma subunit of the heterotrimeric NF-Y transcription factor complex, which specifically binds to CCAAT box motifs in gene promoters to regulate transcription 1. The NF-Y complex consists of NFYB/NFYC heterodimer containing histone fold domains and the sequence-specific NFYA subunit 2. NFYC demonstrates context-dependent regulatory functions through isoform-specific mechanisms. The NFYC-37 isoform promotes tumor growth by interacting with CBP and SREBP2 to activate the mevalonate pathway and cholesterol biosynthesis in bladder cancer, while NFYC-50 recruits CARM1 to methylate CBP and inhibit this pathway 3. NFYC also regulates inflammatory responses in skeletal muscle, where its silencing increases IL6 and LIF cytokine expression 4. The gene functions as an oncogene in choroid plexus carcinomas through chr1 gains and is required for disease initiation and progression 1. Additionally, NFYC participates in oocyte formation as an oocyte-specific transcription factor 5 and promotes mitochondrial transfer in hepatocellular carcinoma under hypoxic conditions through RHOT1 regulation 6. Clinical significance includes its overexpression in various cancers and association with poor prognosis 23.