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GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 15 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
PPIAL4C
peptidylprolyl isomerase A like 4C
Chromosome 1 Β· 1q21.2
NCBI Gene: 653598Ensembl: ENSG00000288867.1HGNC: HGNC:33995UniProt: A0A0B4J2A2
9PubMed Papers
5Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
peptidyl-prolyl cis-trans isomerase activitycyclosporin A bindingprotein foldingcytoplasmatopic eczemaneoplasmcancerliposarcoma
✦AI Summary

Based on limited published evidence, PPIAL4C encodes a peptidylprolyl isomerase that catalyzes cis-trans isomerization of proline imidic peptide bonds, facilitating protein folding. The protein localizes to the cytoplasm and binds cyclosporin A. A lncRNA derived from the PPIAL4C locus (lnc-PPIAL4C-4) was identified in co-expression network analysis associated with gastric cancer peritoneal metastasis 1, though direct protein function in this context remains unclear.

Sources cited
1
lnc-PPIAL4C-4 identified as part of blue module correlated with gastric cancer peritoneal metastasis through WGCNA analysis
PMID: 36690975
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜5
atopic eczemaOpen Targets
0.03Suggestive
neoplasmOpen Targets
0.00Suggestive
cancerOpen Targets
0.00Suggestive
liposarcomaOpen Targets
0.00Suggestive
osteosarcomaOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
NFYCShared pathway100%NKTRShared pathway100%PPICShared pathway100%ST13Shared pathway100%CDC123Shared pathway100%CCT6BShared pathway100%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
PPIAL4CNFYCNKTRPPICST13CDC123CCT6B
PROTEIN STRUCTURE
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AlphaFoldAI-predicted Β· UniProt A0A0B4J2A2
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.83LoF Tolerant
pLIβ“˜
0.34Tolerant
Observed/Expected LoF0.00 [0.00–1.83]
RankingsWhere PPIAL4C stands among ~20K protein-coding genes
  • #17,418of 20,598
    Most Researched9
  • #16,740of 17,882
    Most Constrained (LOEUF)1.83
Genes detectedPPIAL4C
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Identification and validation of crucial lnc-TRIM28-14 and hub genes promoting gastric cancer peritoneal metastasis.
PMID: 36690975
BMC Cancer Β· 2023
1.00