NRXN2 is a presynaptic cell adhesion molecule that functions as a synaptic organizer critical for neurodevelopment and neuropsychiatric health 1. As part of the neurexin family (NRXN1, NRXN2, NRXN3), NRXN2 interacts with postsynaptic neuroligins to regulate synaptic assembly and function 2. At the molecular level, NRXN2 acts as a context-dependent specifier of synapse properties and maintains the balance between excitatory and inhibitory neurotransmission (E/I balance), a process essential for normal neural development 3. Genetic variants in NRXN2 are associated with multiple neurodevelopmental and neuropsychiatric disorders. Homozygous NRXN2 mutations cause severe phenotypes including global developmental delay, severe intellectual disability, epilepsy, and speech delay 4. Heterozygous NRXN2 variants contribute to autism spectrum disorder (ASD) and early infantile epileptic encephalopathy (EIEE) 3, with digenic NRXN1/NRXN2 variants associated with respiratory dysfunction and seizures 5. Clinically, NRXN2 dysfunction disrupts proper alternative splicing patterns during brain development 6 and reduces astrocyte-neuron interactions during aging 7. These findings establish NRXN2 as a critical determinant of normal synaptic function and brain development, with mutations causing severe neurological consequences.