NSL1 is a component of the MIS12 kinetochore complex essential for chromosome 1 and segregation during mitosis. However, the provided abstracts do not directly address NSL1's primary kinetochore function. Instead, they reveal that KANSL1 (a related NSL complex component) has critical roles beyond mitosis. KANSL1 regulates mitophagy through PINK1-dependent pathways and modulates autophagosome-lysosome fusion via transcriptional control of STX17 1, 2. Loss of KANSL1 function causes Koolen-de Vries syndrome (KdVS), characterized by intellectual disability, cardiac abnormalities, seizures, and multi-organ developmental defects 3, 4. In KdVS patients, impaired mitophagy leads to defective mitochondrial clearance and neuronal dysfunction 2. Additionally, NSL1 appears relevant to cellular health, as it was identified in genome-wide association studies for telomere length in cattle 5 and detected in gene fusion events in uterine sarcomas 6, 7. The NSL complex's role in autophagy-mitophagy regulation represents a key mechanism linking NSL1 dysfunction to neurodegeneration and developmental disease. 13-cis retinoic acid shows promise as a therapeutic strategy for KdVS by restoring autophagosome-lysosome fusion 2.