NUDC (nuclear distribution C) is a highly conserved dynein complex regulator essential for cell division and cytoskeletal organization. Functionally, NUDC stabilizes components of the LIS1/dynein complex through its conserved p23 chaperone domain 1, enabling proper mitotic spindle formation and chromosome 1 2. NUDC downregulation causes defective spindle architecture with multiple poles rather than normal bipolar structures, significantly inhibiting cell proliferation 2. Beyond mitosis, NUDC regulates postmitotic functions including dynein-mediated organelle trafficking and actin cytoskeletal reorganization via cofilin stabilization 3. In hematopoiesis, NUDC is highly expressed in early progenitors and dysregulated in acute leukemias (ALL/AML), implicating it in leukemogenesis 4. Clinically, NUDC expression correlates with gastric cancer prognosis, with NUDC-positive tumors showing significantly better overall survival (53.2 vs 44.6 months) 5. In bladder cancer, elevated NUDC stability through RNF41 loss promotes metastasis via enhanced β-tubulin polymerization 6. The RNF41-NUDC-tubulin axis represents a potential therapeutic target for cancer progression. NUDC's roles extend to cell migration, ciliogenesis, and inflammatory responses 1, establishing it as a multifunctional regulator with significant disease relevance.