NUP88 is a nucleoporin component of the nuclear pore complex (NPC) that mediates nucleocytoplasmic transport, including mRNA and ribosomal subunit export from the nucleus 1. Beyond canonical nuclear transport, NUP88 has critical roles in cell cycle regulation. NUP88 interacts with glutamine synthetase to prevent NUP88 binding to CDC20, thereby licensing anaphase-promoting complex (APC/C) activation and ensuring proper metaphase-to-anaphase transition 2. When overexpressed, NUP88 sequesters NUP98-RAE1 from APC/C-CDH1, triggering premature proteolysis of polo-like kinase 1 (PLK1) and causing chr17 instability and aneuploidy 3. NUP88 overexpression also promotes cancer cell migration and invasion through matrix metalloproteinase-12 (MMP-12) upregulation 4. Clinically, NUP88 is frequently overexpressed across diverse human malignancies—including carcinomas, sarcomas, melanomas, and gliomas—correlating with aggressive phenotypes and reduced survival 56. Additionally, NUP88 mutations are associated with fetal akinesia deformation sequence 4. The protein also functions in germ granule organization, anchoring these structures to nuclear pores alongside other nucleoporins 1.