NDC1 (NDC1 transmembrane nucleoporin) is a conserved transmembrane nucleoporin that serves as a critical structural component of nuclear pore complexes (NPCs) 1. The protein plays an essential role in NPC and nuclear envelope assembly by forming links between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring NPCs in the membrane 1. NDC1 functionally interacts with soluble nucleoporins including Nup93, Nup53, and Nup205, with direct binding demonstrated between NDC1 and Nup53 1. Beyond its structural role, NDC1 is required for recruitment of ALADIN to the nuclear envelope and post-mitotic NPC insertion 2. Pathogenic biallelic NDC1 variants that interfere with ALADIN binding are associated with a neurodevelopmental disorder characterized by intellectual disability, severe demyelinating polyneuropathy, alacrima, and achalasia - resembling triple A syndrome but without adrenal insufficiency 2. In cancer contexts, NDC1 is overexpressed in multiple tumor types and associated with poor prognosis, with oncogenic effects demonstrated in acute myeloid leukemia and hepatocellular carcinoma 34. NDC1 also plays roles in male fertility, affecting spermatogenesis through interactions with head-tail coupling apparatus proteins 5.