OLFM3 (olfactomedin 3) is a secreted protein that plays diverse roles in neurological disorders and cancer biology. In neurodevelopment and neurological conditions, OLFM3 shows altered expression patterns associated with disease states. In pediatric PTSD, differential DNA methylation of OLFM3 is associated with anterior hippocampal volume abnormalities 1. The gene is also identified as part of a mitochondrial signature in Alzheimer's disease, where it emerges as a potential biomarker in cortex and serum analyses 2. A novel Parkinson's disease locus near OLFM3 on chromosome 1 has been identified through stratified genome-wide association studies 3. In autism spectrum disorders, OLFM3 is closely related to ZIC transcription factors in cerebellar pathology and shows good diagnostic accuracy 4. Beyond neurological contexts, OLFM3 demonstrates oncological significance by contributing to anoikis resistance in lung cancer cells, where high expression correlates with increased cell survival in suspension culture, and siRNA knockdown increases apoptosis 5. The protein is also incorporated into prognostic models for esophageal cancer as a high-risk anoikis-related gene 6. Additionally, OLFM3 genetic variants show suggestive association with pregnancy-related linea nigra, a pigmentation phenotype 7.