OR1E2 encodes an olfactory receptor protein functioning as a G-protein coupled signaling receptor. Based on limited published evidence, OR1E2 is involved in odorant detection and sensory perception of chemical stimuli through plasma membrane-localized receptor activity. Molecular docking studies suggest OR1E2 binds aroma compounds including δ-decalactone and 2-acetylpyrrole with binding affinity ≤-5.0 kcal/mol 1, implicating its role in human aroma perception. OR1E2 peptides were detected in plasma proteomics studies 2, though functional significance in non-olfactory contexts remains unclear.