OR1G1 is an olfactory receptor belonging to the G protein-coupled receptor (GPCR) superfamily that functions as an odorant receptor mediating olfactory perception. OR1G1 localizes preferentially to intracellular compartments in lung epithelial cells and activates signaling cascades involving increased intracellular calcium concentration upon agonist binding 1. The receptor recognizes a specific repertoire of odorants including nonanal, nonanol, and decenol, with binding occurring through interactions in transmembrane domains 3-6 involving conserved residues E3.39 and H6.40 2. OR1G1 contributes to the combinatorial coding of waxy, fatty, and rose odors in humans 3. Beyond its nasal function, OR1G1 is expressed in lung epithelial cells where activation by odorant ligands reduces cell viability and triggers pro-inflammatory cytokine release (IL-6 and IL-8), suggesting involvement in odorant-induced asthma pathogenesis 1. Olfactory receptor polymorphisms, including OR1G1 variants, influence pleasantness ratings during odor perception testing 4. Notably, reduced OR1G1 expression was observed in COVID-19 patients with chemosensory impairment, linking this receptor to metallic taste perception 5. Rare variants in OR1G1 were identified in a large Parkinson's disease burden analysis, though replication across independent datasets was unsuccessful 6. OR1G1 represents a potential drug target for modulating non-type 2 inflammatory airway diseases.