OR2A4 is a G-protein coupled olfactory receptor expressed in non-olfactory tissues including skin, melanocytes, and hair follicles 12. As an odorant receptor, OR2A4 binds ligands such as cyclohexyl salicylate, triggering intracellular signaling cascades including cAMP and Ca2+ elevation 12. In keratinocytes, OR2A4 activation modulates cytokinesis, cell proliferation, and phosphorylation of AKT and Chk-2, with increased IL-1 secretion 1. OR2A4 localizes to cytokinetic structures and its knockdown causes cytokinesis failure through effects on actin cytoskeleton organization, suggesting a role in cell division regulation 3. In melanocytes, OR2A4 stimulation enhances melanin biosynthesis while inhibiting growth and promoting differentiation via p38 MAPK phosphorylation 2. Clinically, OR2A4 activation with cyclohexyl salicylate promotes hair growth by delaying catagen and expanding epithelial stem cell populations (CD34+) and transit-amplifying cells (CD71+) in hair follicles 4. Additionally, OR2A4 expression increases with perfumed oil application and correlates with improved tactile sensitivity and skin elasticity 5. OR2A4 expression is downregulated in diabetic foot skin, potentially contributing to impaired wound healing 6.