HomeAboutRankingsData Sources
Β© 2026 GeneE
🧬
GeneE
1 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
OR51G2
olfactory receptor family 51 subfamily G member 2
Chromosome 11 Β· 11p15.4
NCBI Gene: 81282Ensembl: ENSG00000176893.6HGNC: HGNC:15198UniProt: Q8NGK0
4PubMed Papers
8Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Receptor
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
plasma membraneolfactory receptor activitysystem processG protein-coupled receptor signaling pathwayalcohol drinkingprostate carcinomagastric cancersmall cell lung carcinoma
✦AI Summary

OR51G2 is an olfactory receptor that localizes to the plasma membrane. Based on limited published evidence, OR51G2 functions as an odorant receptor with ligand-binding capability. A machine learning analysis of gastric cancer identified OR51G2 as a potential independent risk gene in fatty acid metabolism-related subtypes 1; however, immunohistochemical validation showed no significant expression differences between gastric cancer and adjacent tissues 1, suggesting its role in gastric cancer pathology remains unclear.

Sources cited
1
OR51G2 identified as independent risk gene in gastric cancer fatty acid metabolism subtypes but showed no expression differences by immunohistochemistry
PMID: 39439917
⚠Limited data available β€” This gene has 1 indexed publication. Summary and analysis may be incomplete.
Disease Associationsβ“˜8
alcohol drinkingOpen Targets
0.03Suggestive
prostate carcinomaOpen Targets
0.02Suggestive
gastric cancerOpen Targets
0.01Suggestive
small cell lung carcinomaOpen Targets
0.01Suggestive
gastric adenocarcinomaOpen Targets
0.01Suggestive
gastric carcinomaOpen Targets
0.00Suggestive
diabetes mellitusOpen Targets
0.00Suggestive
neoplasmOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
OR51A2Shared pathway100%OR51A4Shared pathway100%OR51C1Shared pathway100%OR56A5Shared pathway100%OR56A3Shared pathway100%OR56B2Shared pathway100%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
OR51G2OR51A2OR51A4OR51C1OR56A5OR56A3OR56B2
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q8NGK0
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.58LoF Tolerant
pLIβ“˜
0.00Tolerant
Observed/Expected LoF1.01 [0.67–1.58]
RankingsWhere OR51G2 stands among ~20K protein-coding genes
  • #18,664of 20,598
    Most Researched4
  • #15,565of 17,882
    Most Constrained (LOEUF)1.58
Genes detectedOR51G2
Sources retrieved1 papers
Response timeβ€”
πŸ“„ Sources
1
1
Identification of Fatty Acid Metabolism-Related Subtypes in Gastric Cancer Aided by Machine Learning.
PMID: 39439917
Cancer Manag Res Β· 2024
1.00