PAK2 is a serine/threonine protein kinase that serves as a downstream effector of small GTPases CDC42 and RAC1, playing crucial roles in multiple cellular processes including cytoskeleton regulation, cell motility, and survival signaling 1. Upon activation by GTP-bound CDC42 and RAC1, PAK2 undergoes conformational changes and autophosphorylation, enabling it to phosphorylate numerous substrates including MAPK4, MAPK6, JUN, and histone H4 1. In cancer contexts, PAK2 promotes cell proliferation and survival through the EGFR-PAK2-ERK5 signaling axis, as demonstrated in hepatocellular carcinoma where FGFR inhibition leads to feedback activation of this pathway 2. PAK2 also regulates RNA methylation by phosphorylating METTL3, promoting its acetylation and spatial control of m6A deposition on chr3-associated RNAs 3. In fibrotic diseases, PAK2 activation drives myofibroblast differentiation and collagen production in idiopathic pulmonary fibrosis, making it a potential therapeutic target 4. Additionally, PAK2 enhances CAR T cell survival by preventing activation-induced cell death 5 and promotes neuroprotection following stroke through the miR-130b-5p/PAK2 signaling pathway, inducing protective endoplasmic reticulum stress 6. These diverse functions position PAK2 as both a therapeutic target in cancer and fibrosis and a protective factor in cellular stress responses.