PARD6A encodes Par6α, an adapter protein essential for cell polarity and asymmetrical cell division 1. It functions as a key component of the Par-aPKC polarity complex, linking GTP-bound Rho small GTPases to atypical protein kinase C proteins and regulating centrosome organization through recruitment of proteins controlling microtubule organization [UniProt]. In normal epithelial cells, PARD6A associates with PARD3 to regulate apicobasal polarity and podocyte morphology 2, while also promoting macropinocytosis in response to metabolic stress through Par3 relocation to microtubules 3. Clinically, PARD6A is frequently upregulated in multiple cancer types with significant disease relevance. In lung adenocarcinoma, PARD6A promotes cell proliferation, migration, and invasion through Serpina3 induction and correlates with poor prognosis 4. In ovarian cancer, PARD6A drives epithelial-mesenchymal transition via the integrin β1-ILK-SNAIL1 pathway, promoting metastasis and correlating with advanced tumor stages 5. In gastric cancer, PARD6A modulates TGFβ receptor signaling through interaction with FOXN2, facilitating cancer progression 6. These findings establish PARD6A as an oncogenic factor and potential therapeutic target across multiple malignancies.