PARD6G (par-6 family cell polarity regulator gamma) is an adapter protein that plays a critical role in asymmetrical cell division and cell polarization. It functions as part of the PARD6-PARD3 complex, which links GTP-bound Rho small GTPases to atypical protein kinase C proteins, contributing to epithelial tight junction formation 1. The gene is implicated in multiple biological processes including centrosome cycle regulation, apical plasma membrane organization, and cellular localization control. At the epigenetic level, PARD6G-AS1 (the antisense RNA associated with PARD6G) functions as an imprinted gene with parent-of-origin-dependent DNA methylation asymmetry 1. This lncRNA participates in immune-related competing endogenous RNA networks, specifically in the PARD6G-AS1/miR-125b-5p/IL24 axis, which may influence immune cell activity in hepatic ischemia-reperfusion injury 2. Clinically, polymorphic imprinted methylation at PARD6G is associated with phenotypic variation 3, and genetic predisposition toward higher PARD6G expression shows a causal relationship with frozen shoulder susceptibility 4. Additionally, CpG methylation sites at PARD6G are significantly associated with telomere length in childhood 5 and with aggressive behavior in adults 6. PARD6G expression is also differentially regulated between lung cancer subtypes 7, and its disruption impairs osteoblast function and bone mineral density 8.