PCBP2 (poly(rC) binding protein 2) is an RNA-binding protein that plays crucial roles in RNA metabolism and cellular homeostasis. PCBP2 functions as an iron chaperone, facilitating safe transport of ferrous iron (Fe2+) in the cytosol to prevent oxidative damage 1. The protein also serves as an adaptor for NAT10-mediated mRNA N-4-acetylcytidine (ac4C) modification, working with TDP43 to recruit NAT10 to cytidine-rich sequences for RNA acetylation 2. In cancer contexts, PCBP2 exhibits dual functions: it promotes malignant progression by stabilizing SLC7A11 mRNA and inhibiting ferroptosis in bladder cancer 3, and confers olaparib resistance in BRCA-mutated breast cancer by stabilizing PARP1 mRNA through inhibition of m6A methylation 4. PCBP2 expression correlates with cancer stemness and immunotherapy resistance across multiple tumor types 5. In neurodegenerative disease, PCBP2 forms pathological biomolecular condensates in Alzheimer's disease, sequestering mitochondrial and RNA-binding proteins, leading to mitochondrial dysfunction and amyloid deposition 6. These diverse functions position PCBP2 as a potential therapeutic target across multiple diseases, with inhibitors showing promise in cancer and neurodegeneration treatment.