KCNG1 (Kv6.1) is a regulatory alpha-subunit of voltage-gated potassium channels that functions as a non-pore-forming subunit. When coassembled with KCNB1 or KCNB2, KCNG1 modulates channel expression and gating kinetics by affecting deactivation upon repolarization and inactivation during sustained depolarization 1. KCNG1 does not form functional channels independently but contributes to heteromeric Kv2/KvS channels that predominate in dorsal root ganglion neurons, where they can be pharmacologically distinguished from Kv2-only channels 23. Genetically, KCNG1 variants associate with multiple disease phenotypes. A common variant near KCNG1 was identified in a multi-ancestry Alzheimer's disease GWAS, suggesting involvement in neurodegeneration 4. A heterozygous KCNG1 missense variant (p.Trp416Cys) in a bovine model caused myotonia congenita with craniofacial dysmorphism and myelodysplasia, implicating KCNG1 in neurodegeneration 5. Elevated KCNG1 expression characterizes triple-negative breast cancer and correlates with sensitivity to platinum-based chemotherapy, with guanidine hydrochloride identified as a potential KCNG1 inhibitor 6. Additionally, a KCNG1-proximal variant modifies the protective association between physical activity and colorectal cancer risk 7, and KCNG1 expression predicts cervical cancer radiotherapy sensitivity 8.