PDE4C (phosphodiesterase 4C) is a cyclic AMP-specific phosphodiesterase that hydrolyzes the second messenger cAMP, playing a crucial role in regulating intracellular signaling pathways 1. The gene is located on chromosome 19.1 and spans at least 38 kb with multiple alternatively spliced variants that show tissue-specific expression patterns, particularly in lung and testis 21. PDE4C functions as a negative regulator of cAMP/PKA signaling, with its activity directly impacting cellular processes including apoptosis, migration, and calcium homeostasis 34. In cancer contexts, PDE4C appears to function as a tumor suppressor, being downregulated through promoter hypermethylation in high-grade gliomas, where reduced expression correlates with poor prognosis and decreased overall survival 3. The enzyme's role extends to reproductive biology, where aberrant upregulation impairs endometrial decidualization by suppressing cAMP levels and FOXO1 expression, contributing to infertility in adenomyosis patients 4. Additionally, PDE4C serves as a therapeutic target in spinal cord injury, where its suppression by miR-615-3p activates the cAMP/PKA pathway, providing neuroprotective effects through improved calcium signaling and reduced endoplasmic reticulum stress 5.