1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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17PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLETumor Suppressor
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingregulation of cell cyclecell peripheryplasma membranecutaneous melanomamale reproductive organ cancerpreeclampsiaadolescent idiopathic scoliosis
Based on limited published evidence, PGCKA1 acts as a tumor suppressor. It suppresses cell proliferation when overexpressed 1 and functions in the PDCD10-GCKIII kinase module. In colorectal cancer, PGCKA1 exerts tumor suppressive activity by targeting the KEAP1/USP17/ELK1/CDK6 axis to inhibit cell proliferation 2. The gene is located on chromosome 4, which shows recurrent deletion in basal breast cancer, suggesting loss of PGCKA1 contributes to enhanced tumor proliferation 1.
1
PGCKA1 (C4orf19) suppresses proliferation when overexpressed; located on chr4p which is recurrently deleted in basal breast cancer
PMID: 385178862
PGCKA1 acts as tumor suppressor in colorectal cancer by targeting KEAP1/USP17/ELK1/CDK6 axis
PMID: 36882524⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
cutaneous melanomaOpen Targets
male reproductive organ cancerOpen Targets
adolescent idiopathic scoliosisOpen Targets
esophageal cancerOpen Targets
cholelithiasisOpen Targets
Hyperlipoproteinemia type 1Open Targets
familial apolipoprotein C-II deficiencyOpen Targets
immunodeficiency 80 with or without congenital cardiomyopathyOpen Targets
chronic obstructive pulmonary diseaseOpen Targets
nonpapillary renal cell carcinomaOpen Targets
familial lipoprotein lipase deficiencyOpen Targets
colorectal cancerOpen Targets
Iron deficiency anemiaOpen Targets
medulloblastomaOpen Targets
colorectal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.