PIK3C2A is a Class II phosphatidylinositol 3-kinase that catalyzes phosphorylation of phosphatidylinositol to generate PI(3)P and PI(3,4)P2 second messengers 1. These lipids regulate diverse cellular processes including proliferation, metabolism, and cell motility 2. Functionally, PIK3C2A is essential for primary cilia formation and maintenance, clathrin-mediated endocytosis, and cytokinetic abscission through ESCRT-dependent mechanisms 32. The protein participates in receptor-mediated endocytosis at the ciliary base and regulates metabolic pathways including mTORC1 signaling 45. Dysregulation of PIK3C2A is associated with multiple pathological conditions. Loss-of-function mutations cause oculoskeletodental syndrome characterized by short stature, cataracts, skeletal abnormalities, and impaired cilia formation 12. Reduced PIK3C2A expression correlates with acute coronary syndrome development, serving as an independent risk factor for coronary artery disease 6. In renal clear cell carcinoma, PIK3C2A downregulation associates with poor prognosis and altered immune infiltration 7. Conversely, loss of PI3K-C2γ (a related isoform) in pancreatic cancer increases mTORC1 hyperactivation and metabolic vulnerability 4. Post-stroke neurogenesis impairment involves disruption of the CXCL12-PIK3C2A-CREB3L2 axis 5. PIK3C2A suppression via miR-509-3p inhibits cancer cell proliferation and migration 8.