PIK3C2G encodes phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma, a Class II phosphoinositide 3-kinase located on chromosome 12 1. The enzyme generates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,4-bisphosphate as second messengers, regulating diverse cellular processes including proliferation, survival, migration, and intracellular protein trafficking 12. PIK3C2G functions downstream of PI4KIIIα to regulate cytoskeletal reorganization by promoting Akt2 phosphorylation and generating plasma membrane phosphatidylinositol 3,4-bisphosphate-enriched structures that control cell migration and invasiveness 3. Dysregulation of PIK3C2G associates with multiple diseases. In thyroid-associated orbitopathy, PIK3C2G expression is significantly downregulated in orbital adipose-connective tissues, suggesting dysregulation of differentiation and developmental pathways 4. PIK3C2G polymorphisms associate with type 2 diabetes susceptibility and altered fasting insulin levels in Japanese populations 5, and the gene is implicated in diabetic nephropathy 6. In lung adenocarcinoma, PIK3C2G mutations correlate with primary resistance to EGFR-targeted therapies, with significantly shorter progression-free survival 7. PIK3C2G also appears in a prognostic signature for ovarian cancer progression and chemoresistance 8.