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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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PIR
pirin
Chromosome X · Xp22.2
NCBI Gene: 8544Ensembl: ENSG00000087842.12HGNC: HGNC:30048UniProt: O00625
45PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transcription Factor
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nuclear bodytranscription coregulator activityprotein bindingquercetin 2,3-dioxygenase activityCOVID-19neoplasmlung adenocarcinomacolorectal carcinoma
✦AI Summary

Insufficient information available. The provided PubMed abstracts do not contain relevant data about the PIR (pirin) gene on chromosome X. The abstracts discuss unrelated topics: post-isometric relaxation (PIR) therapy for temporomandibular disorders 1, immunological checkpoint inhibitor ILT4 in lung cancer 2, pregnancy-induced rhinitis (PIR) [PMID:23671891; 39], PIWI-interacting RNAs (piRNAs) in cancer including piR-2158 4, piR-823 as a cancer biomarker 5, piR-RCC in renal cell carcinoma 6, and Plasmodium interspersed repeat (pir) genes in malaria parasites 7. None of these abstracts address the human PIR gene, its transcriptional coregulatory function in NF-kappa-B signaling, its quercetin 2,3-dioxygenase activity, or its role in myeloid cell differentiation. To provide an accurate gene function summary with proper citations, peer-reviewed literature specifically investigating the human PIR/pirin protein would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
COVID-19Open Targets
0.36Weak
neoplasmOpen Targets
0.10Suggestive
lung adenocarcinomaOpen Targets
0.10Suggestive
colorectal carcinomaOpen Targets
0.10Suggestive
melanomaOpen Targets
0.09Suggestive
posterior cortical atrophyOpen Targets
0.08Suggestive
renal cell carcinomaOpen Targets
0.08Suggestive
infectionOpen Targets
0.08Suggestive
glioblastoma multiformeOpen Targets
0.08Suggestive
laryngeal squamous cell carcinomaOpen Targets
0.07Suggestive
renal cell adenocarcinomaOpen Targets
0.07Suggestive
oral squamous cell carcinomaOpen Targets
0.07Suggestive
triple-negative breast cancerOpen Targets
0.06Suggestive
asthmaOpen Targets
0.06Suggestive
breast cancerOpen Targets
0.06Suggestive
gastric cancerOpen Targets
0.06Suggestive
nonpapillary renal cell carcinomaOpen Targets
0.06Suggestive
colorectal cancerOpen Targets
0.05Suggestive
esophageal adenocarcinomaOpen Targets
0.05Suggestive
gliomaOpen Targets
0.05Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
BCL3Protein interaction98%PIWIL1Protein interaction97%CTF1Protein interaction91%PIWIL4Protein interaction85%PIWIL2Protein interaction74%GLIS3Shared pathway25%
Tissue Expression6 tissues
Liver
100%
Brain
82%
Ovary
69%
Lung
69%
Bone Marrow
64%
Heart
59%
Gene Interaction Network
Click a node to explore
PIRBCL3PIWIL1CTF1PIWIL4PIWIL2GLIS3
PROTEIN STRUCTURE
Preparing viewer…
PDB6N0K · 1.46 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.30LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.91 [0.65–1.30]
RankingsWhere PIR stands among ~20K protein-coding genes
  • #9,498of 20,598
    Most Researched45
  • #13,668of 17,882
    Most Constrained (LOEUF)1.30
Genes detectedPIR
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Evaluation of the efficacy of manual soft tissue therapy and therapeutic exercises in patients with pain and limited mobility TMJ: a randomized control trial (RCT).
PMID: 37684652
Head Face Med · 2023
1.00
2
ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
PMID: 33537094
Theranostics · 2021
0.90
3
Pregnancy-induced rhinitis.
PMID: 23671891
Rhinology · 2013
0.80
4
Redefining Pregnancy-Induced Rhinitis.
PMID: 32903019
Am J Rhinol Allergy · 2021
0.70
5
IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
PMID: 37153732
Theranostics · 2023
0.60