PITPNA (phosphatidylinositol transfer protein alpha) is a lipid transfer protein that catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between cellular membranes 123. The protein shows substrate specificity, preferring PI and PC species with shorter saturated or monosaturated acyl chains, with preference order C16:1 > C16:0 > C18:1 > C18:0 for both lipid classes 4. In pancreatic beta cells, PITPNA plays a critical metabolic role by stimulating phosphatidylinositol 4-OH kinase activity to generate PtdIns-4-P in the trans-Golgi network, promoting insulin granule maturation and glucose-stimulated insulin secretion 5. PITPNA expression is markedly reduced in Type 2 diabetic human islets, and restoration of PITPNA in these islets reverses beta-cell dysfunction by normalizing insulin processing, granule docking, and proinsulin processing while alleviating ER stress 5. Clinically, the PITPNA locus has gained attention through its antisense RNA transcript PITPNA-AS1, which functions as an oncogenic competing endogenous RNA in multiple malignancies including hepatocellular carcinoma, glioblastoma, and gastric cancer through various microRNA-mediated regulatory axes 678. Notably, in ovarian cancer, PITPNA-AS1 acts as a tumor suppressor by regulating the miR-223-3p/RHOB axis 9. These findings identify PITPNA as a therapeutic target in both metabolic and malignant diseases.