SCARF1 (scavenger receptor class F member 1) is a type I transmembrane protein that functions as a multifaceted scavenger receptor essential for maintaining homeostasis and immunity. The protein forms homodimers with EGF-like domains that adopt a long-curved conformation, enabling recognition of multiple endogenous and exogenous ligands including modified low-density lipoproteins (LDLs) 1. SCARF1 mediates binding and endocytosis of diverse ligands through positively charged residues crucial for interaction with modified LDLs 1. As an efferocytosis receptor, SCARF1 is highly expressed on phagocytic cells where it facilitates clearance of apoptotic cells and initiates anti-inflammatory IL-10 responses through STAT1/STAT3 phosphorylation 2. The protein also serves as a receptor for heat shock proteins and complement C1q, playing roles in antigen processing, immune cell activation, and neutrophil extracellular trap formation 34. SCARF1 deficiency leads to severe autoimmune phenotypes resembling systemic lupus erythematosus due to impaired apoptotic cell clearance 5. Anti-SCARF1 autoantibodies found in 26% of SLE patients correlate with defective efferocytosis, highlighting its clinical significance in autoimmune diseases 2. The receptor also shows therapeutic potential as a targeting mechanism for drug delivery in cardiovascular disease 6.