PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1) is a phospholipid transporter that catalyzes phosphatidylinositol transfer between intracellular membranes 1. As a member of the PITP protein family, PITPNC1 extracts and delivers phosphatidylinositol to specific membrane compartments, enabling phosphoinositide synthesis critical for signal transduction and membrane trafficking 2. Mechanistically, PITPNC1 binds Golgi-resident PI4P and recruits RAB1B to the Golgi network, facilitating GOLPH3-mediated Golgi extension and enhanced vesicular secretion 3. In KRAS-driven cancers, PITPNC1 is regulated by MEK1/2 and JNK1/2 signaling, controlling mTOR localization via MYC stabilization to suppress autophagy 4. Clinically, PITPNC1 is highly relevant to multiple malignancies. In rectal cancer, PITPNC1 suppresses CD8+ T cell immunity through a FASN/CD155 pathway, promoting radioresistance 5. In gastric cancer, elevated PITPNC1 expression promotes anoikis resistance via fatty acid oxidation, facilitating omental metastasis 6. PITPNC1 amplification occurs in breast cancer and is overexpressed in metastatic melanoma and colon cancers, increasing secretion of pro-invasive factors 3. High PITPNC1 serum levels in acute myeloid leukemia independently predict poor overall survival 7. PITPNC1 represents a promising therapeutic target across multiple cancer types 8.