PRELID3A (PRELI domain containing 3A) is a mitochondrial protein involved in phospholipid transport. The primary function of PRELID3A is to facilitate phosphatidic acid (PA) transfer across the mitochondrial intermembrane space as part of a complex with TRIAP1 [UniProt annotation]. This PA transport activity is essential for cardiolipin synthesis in the mitochondrial inner membrane, a critical component of optimal mitochondrial function and energy metabolism. Mechanistically, PRELID3A mediates direct transfer of phosphatidic acid between cellular compartments, functioning as a PA transporter that supports downstream lipid biosynthesis pathways crucial for mitochondrial structure and function. The protein localizes to the mitochondrial intermembrane space and demonstrates phospholipid transport and protein-binding activities [GO Annotations]. Regarding disease relevance, PRELID3A has been identified as part of mitochondrial-nuclear crosstalk networks associated with early-life developmental processes. Newborn mitochondrial DNA copy number was significantly associated with differential DNA methylation at PRELID3A loci, with methylation patterns persisting into childhood and correlating with cognitive development outcomes 1. Additionally, PRELID3A expression is modulated in immune responses, including vitamin D-mediated antiviral responses to Zika virus in macrophages 2. These findings suggest PRELID3A participates in mitochondrial-nuclear communication networks relevant to both developmental neurobiology and immune function, though direct clinical applications require further investigation.