PKD1L2 encodes polycystin-1L2, a member of the TRPP (transient receptor potential polycystic) channel family that functions as a G-protein-coupled receptor 1. The protein contains 11 transmembrane domains, receptor for egg jelly domains, and G-protein-coupled receptor signatures, with multiple splice variants producing proteins of 1775 or 2460 amino acids 1. PKD1L2 demonstrates calcium channel activity and mechanosensitive properties, consistent with its classification as a TRPP channel 2. The protein binds to specific G-protein subunits and associates with fatty acid synthase in skeletal muscle, localizing to costameric regions 13. PKD1L2 plays a critical role in neuromuscular integrity, as upregulation causes severe muscle atrophy, neuromuscular junction degeneration, and myopathy in mice 3. Copy number variations in PKD1L2 are associated with increased colorectal cancer risk, particularly in younger patients and those with higher BMI 4. The gene is also implicated in breast cancer prognosis prediction models and shows altered expression during Zika virus infection in neural cells 56. These findings establish PKD1L2 as a multifunctional channel protein with roles in G-protein signaling, neuromuscular function, and disease susceptibility.