TRPC1 (transient receptor potential cation channel subfamily C member 1) is a calcium-permeable, non-selective cation channel that plays a crucial role in cellular calcium signaling 1. The protein consists of six transmembrane segments and is ubiquitously expressed in human tissues, localizing to the endoplasmic reticulum, plasma membrane, intracellular vesicles, and primary cilium 1. TRPC1 primarily functions within store-operated calcium entry (SOCE) pathways, requiring interactions with STIM1 and Orai1 proteins to mediate non-selective cation currents 2. A key functional characteristic of TRPC1 is its ability to form heteromeric channels with other TRPC family members, particularly TRPC4 and TRPC5, creating channels with distinct ion conduction properties 34. These heteromers exhibit asymmetrically constricted selectivity filters and reduced calcium permeability compared to homomeric channels 3. TRPC1 regulates fundamental cellular processes including proliferation, survival, differentiation, and migration 1. Clinically, TRPC1 has been implicated in colorectal cancer, where it is overexpressed and contributes to enhanced cell proliferation and survival through remodeled calcium signaling 5. The channel is also associated with various diseases including diabetic nephropathy, neurodegenerative disorders, and muscular dystrophy 1. TRPC1/TRPC5 heteromers represent potential therapeutic targets for anxiety and depression treatment 4.