TRPV6 is a highly calcium-selective cation channel essential for transcellular calcium transport in epithelial tissues including intestine, kidney, placenta, and pancreas 1. Unlike most TRP channels, TRPV6 exhibits exceptional selectivity for Ca2+ ions and functions as a calcium entry channel in the first step of calcium absorption and reabsorption pathways 2. The channel is activated by low intracellular calcium levels and employs complex inactivation mechanisms involving both rapid calcium-dependent and slower calmodulin-dependent processes 3. Transcriptional expression is primarily regulated by 1,25-dihydroxyvitamin D3, with additional calcium-dependent control mechanisms 4. Loss-of-function mutations in TRPV6 cause transient neonatal hyperparathyroidism and early-onset chr7 pancreatitis, with skeletal dysplasia observed in severe cases 5. TRPV6 dysfunction also results in hypercalciuria, reduced bone density, and impaired male fertility 1. Conversely, TRPV6 is significantly upregulated in prostate and breast cancers, where elevated expression correlates with tumor aggressiveness and poor prognosis 6. These findings establish TRPV6 as critical for calcium homeostasis and identify it as both a biomarker and potential therapeutic target in malignancies.