Based on limited published evidence, PLPP7 is an inactive phospholipid phosphatase localized to the nuclear envelope and membrane that functions as a negative regulator of myoblast differentiation, partly through effects on MTOR signaling. Despite lacking detectable enzymatic activity, PLPP7 is associated with myopathy phenotypes, as Plpp7 knockout mice exhibit muscle weakness detectable by inverted screen testing 1. The protein's role at the nuclear envelope suggests involvement in muscle nuclear function, though specific mechanisms remain undefined.