TMEM38A (transmembrane protein 38A), also known as TRIC-A, is a monovalent cation channel located in the sarcoplasmic reticulum (SR) and nuclear envelope membranes 1. As an intracellular potassium counter-ion channel, TMEM38A facilitates rapid intracellular calcium release by functioning in synchronization with SR calcium dynamics and is opened by voltage changes within the SR lumen 1. In excitable tissues, TMEM38A is essential for maintaining proper SR calcium handling; TRIC-A-knockout mice show abnormal calcium dynamics in skeletal and cardiac muscle, and human TMEM38A mutations are associated with stress-induced cardiac arrhythmias 1. Beyond calcium regulation, TMEM38A serves tissue-specific functions in myogenesis, where it directs developmental genes to the nuclear periphery for repression, contributing approximately one-third to two-thirds of gene repression during muscle differentiation 2. Clinically, elevated TMEM38A expression correlates with improved radiotherapy sensitivity in cervical cancer and acts as a tumor suppressor in renal cell carcinoma, where its overexpression induces apoptosis and G2/M phase arrest 34. TMEM38A expression is downregulated in ischemic stroke pathogenesis 5 and represents a potential therapeutic target in chr19 myeloid leukemia 6.