PLPPR2 (phospholipid phosphatase related 2) is a lipid phosphate phosphatase that catalyzes phospholipid dephosphorylation and participates in phospholipid metabolic processes 1. The protein functions primarily in lipid raft formation and signaling, where it alters lipid raft composition by modulating levels of esters, sphingomyelin, and sphingosine 2. PLPPR2 localizes to the plasma membrane and endoplasmic reticulum, positioning it to regulate both extracellular and intracellular bioactive lipid phosphates 3. In disease contexts, PLPPR2 has emerged as a significant biomarker in cardiovascular and malignant pathologies. It was identified as one of five key lipid metabolism-related biomarkers in myocardial infarction, with altered expression distinguishing MI patients from controls (AUC >0.7) 1. In early-stage lung adenocarcinoma, elevated PLPPR2 levels function as an independent prognostic risk factor, driving excessive cell proliferation through enhanced lipid raft-mediated proliferation 2. Additionally, PLPPR2 knockout mice exhibited previously undetected myopathic lesions on histopathology 4, suggesting roles in skeletal muscle homeostasis. PLPPR2 expression is also dysregulated in neuroinflammatory conditions, where it represents a biomarker of LPS-induced brain inflammation reversible by therapeutic intervention 5. These findings collectively position PLPPR2 as a multifunctional regulator with diagnostic and therapeutic potential across cardiovascular, oncologic, and neurological diseases.