2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
14PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
phosphatidate phosphatase activityphospholipid metabolic processsignal transductionphospholipid dephosphorylationglaucomaopen-angle glaucomauterine fibroidAbnormality of refraction
Based on limited published evidence, PLPPR3 is a phospholipid phosphatase with predicted phosphatidate phosphatase activity involved in phospholipid dephosphorylation and metabolic processes at the plasma membrane. The protein functions in signal transduction pathways. PLPPR3 was identified as a cell-surface marker for purifying human primitive undifferentiated spermatogonia enriched for spermatogonial stem cells 1. Additionally, miR-3187-5p and miR-3187-3p binding sites have been identified in PLPPR3 mRNA, suggesting post-transcriptional regulation 2.
1
PLPPR3 identified as a cell-surface protein for purifying human primitive undifferentiated spermatogonia enriched for spermatogonial stem cells
PMID: 326611782
miR-3187-5p and miR-3187-3p binding sites identified in PLPPR3 mRNA coding sequence
PMID: 31397443⚠Limited data available — This gene has 2 indexed publications. Summary and analysis may be incomplete.
open-angle glaucomaOpen Targets
uterine fibroidOpen Targets
Abnormality of refractionOpen Targets
kidney failureOpen Targets
diabetes mellitusOpen Targets
gestational diabetesOpen Targets
type 2 diabetes mellitusOpen Targets
low tension glaucomaOpen Targets
anti-neutrophil antibody associated vasculitisOpen Targets
glioblastoma multiformeOpen Targets
anaplastic large cell lymphomaOpen Targets
endometrial carcinomaOpen Targets
acute myeloid leukemiaOpen Targets
No pathogenic variants reported on ClinVar for this gene.