Based on limited published evidence, PLPPR3 is a phospholipid phosphatase with predicted phosphatidate phosphatase activity involved in phospholipid dephosphorylation and metabolic processes at the plasma membrane. The protein functions in signal transduction pathways. PLPPR3 was identified as a cell-surface marker for purifying human primitive undifferentiated spermatogonia enriched for spermatogonial stem cells 1. Additionally, miR-3187-5p and miR-3187-3p binding sites have been identified in PLPPR3 mRNA, suggesting post-transcriptional regulation 2.